Wednesday, April 3, 2013

Disney halts game development at LucasArts, moves to licensed Star Wars titles

Disney shuts down game development at LucasArts, moves to licensed Star Wars games

If you're old enough to have played PC games for more than a decade, LucasArts (originally LucasFilm Games) likely has a permanent place in your heart after a string of legendary adventure and flight combat releases. You'll unfortunately have to put the company as you knew it squarely in the past -- Lucasfilm's new owner, Disney, is ending internal development at LucasArts. The software house is shifting to a licensing model for Star Wars games, reportedly "minimizing the company's risk" while expanding the range of games on offer. There's a chance that in-progress titles like Star Wars 1313 will survive with outside help, according to a spokesperson in touch with GameInformer, but talk of layoffs from Kotaku dampens any chances for direct follow-ups to favorites like Grim Fandango. We won't mourn too much when personas like Ron Gilbert, Lawrence Holland and Tim Schafer have long since moved on to other companies -- still, it's unquestionably the end of an era for game and movie fans alike.

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Via: Joystiq

Source: GameInformer (1), (2)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/e3D85b869SI/

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How the worm turns: Scientists show how a monoamine neurotransmitter acts to coordinate a compound movement through two different receptors in C. elegans

Apr. 2, 2013 ? New research by scientists at the University of Massachusetts Medical School shows at the single cell level how an external stimulus sets off a molecular chain reaction in the transparent roundworm C. elegans, a process in which a single neurotransmitter coordinates and times two separate actions. These findings shed new light on how neurons translate sensory input into actions and may one day pave the way to understanding how misfiring neurons contribute to motor symptoms in neurological diseases such as Parkinson's disease.

Details of the study were published online by PLOS Biology.

"We've known the broad outline of how a behavior circuit works-a stimulus starts a neuronal cascade, which ultimately activates a muscle cell-for decades," said Mark Alkema, PhD, assistant professor of neurobiology. "The details about how this process works, however, such as which neurotransmitters act through which receptors in which neurons have remained a mystery for even the simplest of behaviors.

"This research provides an answer to the simple question of how the worm turns around and the broader question of how a behavioral sequence is produced on a sub-cellular level. In time, understanding voluntary movement in humans will require answering the same questions about the timing and location of neurons and neurotransmitters-only in the infinitely more complex variety of circuits in the human nervous system," said Dr. Alkema.

Roundworms move by alternately relaxing and contracting ventral and dorsal muscles along both sides of its body. As the animal moves forward, it uses its head to probe for possible threats. A gentle touch to the head of the worm initiates an escape response resulting in the animal ceasing head movements and quickly moving backwards. This initial reaction is closely followed by a deep ventral turn allowing it to move away in the opposite direction.

Earlier studies have shown that tyramine, a monoamine neurotransmitter akin to noradrenaline in humans, is involved in the C. elegans escape response. Specifically, C. elegans have a pair of tyraminergic motor neurons that are essential for coordinating the initial suppression of head movement and the backing response. These neurons release tyramine, which works through a fast-acting ion channel called LGC-55 to inhibit forward movement and relax the neck muscles. How the animal coordinates this movement with the subsequent deep turn that allows it to complete the change in direction and move away from the threat, however, was unknown. In this study, the authors provide evidence that links this initial phase of the escape response to the later stages in which the worm makes a sharp turn and navigates away from the danger.

When C. elegans are placed on a surface containing a high concentration of tyramine they become immobilized. Alkema and colleagues found that this paralysis could be overcome by mutating the C. elegans gene responsible for encoding the G-protein coupled receptor SER-2. Additionally, they found that the SER-2 receptor was active in a set of 13 neurons residing along the ventral nerve cord. The synapses of these neurons were connected to corresponding ventral muscles cells along one side of the worm's body.

Further experiments revealed that the same monoamine neurotransmitter-tyramine-responsible for the initial phase of the escape response was also responsible for activating the slow-acting G-protein coupled receptor SER-2. Activation of this receptor inhibited release of the neurotransmitter GABA and facilitated contraction of the ventral muscles, allowing the animal to complete its turn and resume movement in the opposite direction.

"This study shows how tyramine works through separate receptors to produce a complex behavior requiring the temporal coordination of independent motor programs," said Alkema. "Acting through the fast-acting ionotropic receptor LGC-55, the animal completes the initial movement by ceasing head movement and backing away. At the same time, the slow-acting SER-2 receptor is also being activated by tyramine to complete the turn and facilitate movement in the opposite direction.

"It is the different receptors that allow for the coordination of these actions by the same neurotransmitter," said Alkema. "This indicates that tyramine, much like adrenergic signaling in mammals, coordinates different aspects of the flight response. It's possible that temporally coordinated activation of ionotropic and metabotropic receptors may be a common signaling motif employed across organisms to orchestrate behavioral responses and is something we will be pursing further."

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The above story is reprinted from materials provided by University of Massachusetts Medical School, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal References:

  1. Jamie L. Donnelly, Christopher M. Clark, Andrew M. Leifer, Jennifer K. Pirri, Marian Haburcak, Michael M. Francis, Aravinthan D. T. Samuel, Mark J. Alkema. Monoaminergic Orchestration of Motor Programs in a Complex C. elegans Behavior. PLoS Biology, 2013; 11 (4): e1001529 DOI: 10.1371/journal.pbio.1001529
  2. Richard Robinson. How the Worm Turns, in Molecular Detail. PLoS Biology, 2013; 11 (4): e1001526 DOI: 10.1371/journal.pbio.1001526

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/DiYDz4ju1C4/130402182642.htm

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Tuesday, April 2, 2013

Mommyof2Babies: Cake Lingerie Review

Have you ever tried Cake Lingerie?if not and you are a expecting mother or know someone who is this this would be the perfect site for them to go to check out all your nursing, sleepwear, and maternity needs. I?received?the Apple Crumble?Set?which consists of the Top and Bottom that is the perfect sleepwear set. The material is so soft and?comfortable. And all their clothes are so stylish. And the material is very high class.?

Cake was born in 2008 when its founder; Tracey Montford yearned for beautiful lingerie during her pregnancy. All she could find was matronly, high cupped, uninspiring and unflattering product, which did nothing for her self esteem and?

pride, during this period of vulnerability.

She chose to do something about it herself; designing Cake Lingerie to give pregnant and breast-feeding mothers an opportunity to feel feminine again. Made by Mothers for Mothers, every woman deserves the best!

Made from luxurious modal, this nursing camisole is essential for every pregnant and breastfeeding woman. With gathers in the front and sides, this ultra feminine, astonishingly beautiful garment is soft and stretchy with room for a growing tummy. Moderately built in shelf support, ensures for a secure but yet non???restrictive feel at all times.

Which Retails for AUD 49.90

Perfect for nightwear and loungewear, these pants are made from high quality modal cotton that is soft and provides a flattering contoured shape. Perfectly shaped to sit below the belly these pants are trimmed with a lovely lace and they are so comfortable that one pair will not be enough!

Which also Retails for AUD $49.90

I love this sleepwear and will plan to purchase more from them in the near future!!

Disclaimer: I was sent products for free to review for my honest opinion, from either a PR agency or a company. Regardless, I only recommend products or services I use personally and believe will be good for my readers. Your opinions may vary from my opinions.?


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Source: http://mommyyof2babies-introduction.blogspot.com/2013/04/cake-lingerie-review.html

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DNA: How to unravel the tangle

Monday, April 1, 2013

A research coordinated by the scientists at SISSA of Trieste has now developed and studied a numeric model of the chromosome that supports the experimental data and provides a hypothesis on the bundle's function.

A chromosome spends most of its life "diluted" in the nuclear cytoplasm. To the untrained eye it may look like a randomly entangled thread, yet biologists claim the opposite: although a chaotic component does exist in the bundle, experimental measurements have identified regions that tend to contain specific genes. Thanks to such measurements, researchers have obtained maps of the chromosome in its diluted form, the one in which the DNA transcription processes occur.

Cristian Micheletti, a physicist of SISSA, the International School for Advanced Studies of Trieste, has coordinated an international research team - in which Marco Di Stefano and Angelo Rosa stand out - that has devised an ingenious method which, on one hand, has allowed to verify the already known experimental measures and, on the other, to find data in support of a theory which explains why the DNA bundle is arranged in regions. "Employing the vast amount of publicly available data on gene expression, we have identified families of genes co-regulated within a chromosome" explains Micheletti. The co-regulated genes codify "in accord", but how such synchronization occurs is a mystery, since often the genes are located very far from one another on the DNA filament. "Two main hypotheses may be considered: either 'messengers' exist that travel back and forth from one gene to the other and coordinate the activity, or the DNA filament folding up inside the tangle brings the genes belonging to the same family physically close."

On the basis of the second assumption Micheletti and his colleagues have used the computer to induce the DNA numeric model to bring the co-regulated genes closer. "The outcome of the simulation has provided a map of chromosome arrangement that is very close to the one obtained through experimentation," explains Micheletti. "Besides, the model has successfully brought closer the genes belonging to the same family, as we had asked for, in 80% of cases, that is without too much effort, which corroborates the validity of the hypothesis and the effectiveness of the simulation."

The article was chosen by PLOS Computational Biologyjournal as the cover story for the March issue.

###

International School of Advanced Studies (SISSA): http://www.sissa.it

Thanks to International School of Advanced Studies (SISSA) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127533/DNA__How_to_unravel_the_tangle

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Afghan teenager fatally stabs US soldier

KABUL, Afghanistan (AP) ? An Afghan teenager killed an American soldier in eastern Afghanistan by stabbing him in the neck while he played with a group of local children, officials said Monday.

The killing comes as the monthly U.S. death toll rose sharply in March to 14 with the start of the spring fighting season when the Taliban and other insurgents take advantage of improved weather to step up attacks.

Sgt. Michael Cable, 26, was guarding Afghan and U.S. officials meeting in a province near the border with Pakistan when the stabbing occurred last Wednesday, two senior U.S. officials said. They spoke on condition of anonymity because the investigation is ongoing.

The attack occurred after the soldiers had secured the area for the meeting, but one of the U.S. officials said the youth was not believed to have been a member of the Afghan security forces or in uniform so it was not being classified as an insider attack.

The official said the attacker was thought to be about 16 years old, but the age couldn't be verified.

The Afghan and American dignitaries were attending the swearing-in ceremony of Afghan Local Police in Shinwar district in Nangarhar province, senior district official Zalmai Khan said. Afghan Local Police, or ALP, recruits are drawn from villages and backed by the U.S. military.

The soldier was playing with a group of children outside when the attacker came from behind and stabbed him in the neck with a large knife, Khan said, adding the young man had escaped to nearby Pakistan.

Taliban spokesman Zabiullah Mujahid said the young man was acting independently when he killed the soldier but had joined the Islamic militant movement since fleeing the scene.

The Pentagon said in a statement last week that Cable, of Philpot, Ky., died from injuries sustained when his unit was attacked by enemy forces.

At least 14 U.S. soldiers died in March, compared with four in the previous two months, according to an Associated Press tally.

The number of American troops killed in Afghanistan has dropped sharply as international forces increasingly take a back seat while preparing to end their combat mission by the end of 2014. But they continue to face dangers ranging from roadside bombs to attacks by their Afghan counterparts or insurgents disguised as government forces.

___

Associated Press writers Kimberly Dozier and Amir Shah contributed to this report.

Source: http://news.yahoo.com/afghan-teenager-fatally-stabs-us-soldier-105007454.html

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6,000 Syrians killed in March, deadliest month yet

FILE - This file citizen journalism image taken on, Sunday, March. 10, 2013 and provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows Syrians standing next to dead bodies that have been pulled from the river near Aleppo's Bustan al-Qasr neighborhood, Syria. More than 6,000 people were killed in the Syrian civil war in March alone, according to a leading activist group that reported it was the deadliest month yet in the 2-year-old conflict. (AP Photo/Aleppo Media Center AMC, File)

FILE - This file citizen journalism image taken on, Sunday, March. 10, 2013 and provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows Syrians standing next to dead bodies that have been pulled from the river near Aleppo's Bustan al-Qasr neighborhood, Syria. More than 6,000 people were killed in the Syrian civil war in March alone, according to a leading activist group that reported it was the deadliest month yet in the 2-year-old conflict. (AP Photo/Aleppo Media Center AMC, File)

FILE - In this Wednesday, March 13, 2013 photo released by the Syrian official news agency SANA, Syrian doctors treat a man who was wounded at the scene where two mortar rounds exploded near an orphanage, at al-Boukhtyar area, in Damascus, Syria. More than 6,000 people were killed in the Syrian civil war in March alone, according to a leading activist group that reported it was the deadliest month yet in the 2-year-old conflict. (AP Photo/SANA, File)

FILE - In this Thursday, March 28, 2013 photo released by the Syrian official news agency SANA, a Syrian doctor treats an injured man who was wounded at the open-air cafeteria at Damascus University in the central Baramkeh district, in Damascus, Syria. More than 6,000 people were killed in the Syrian civil war in March alone, according to a leading activist group that reported it was the deadliest month yet in the 2-year-old conflict. (AP Photo/SANA, File)

FILE - This Friday, March 1, 2013 file citizen journalism image provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows a Syrian child, injured by heavy bombing from military warplanes, in the town of Hanano in Aleppo, Syria. More than 6,000 people were killed in the Syrian civil war in March alone, according to a leading activist group that reported it was the deadliest month yet in the 2-year-old conflict. (AP Photo/Aleppo Media Center AMC, File)

FILE - In this Thursday, March 21, 2013 photo released by the Syrian official news agency SANA, Syrian doctors treat an injured man who was wounded at the Eman Mosque where a suicide bomber blew himself up, killing Sheikh Mohammad Said Ramadan al-Buti, an 84-year-old cleric known to all Syrians as a religious scholar, at the Mazraa district, in Damascus, Syria. More than 6,000 people were killed in the Syrian civil war in March alone, according to a leading activist group that reported it was the deadliest month yet in the 2-year-old conflict. (AP Photo/SANA, File)

(AP) ? March was the bloodiest month yet in Syria's 2-year-old conflict with more than 6,000 documented deaths, a leading anti-regime activist group said Monday, blaming the increase on heavier shelling and more violent clashes.

Rami Abdul-Rahman, who heads the Syrian Observatory for Human Rights, said the increased toll is likely incomplete because both the Syrian army and the rebel groups fighting President Bashar Assad's government often underreport their dead in the civil war.

"Both sides are hiding information," Abdul-Rahman said by phone from Britain, where his group is based. "It is very difficult to get correct info on the fighters because they don't want the information to hurt morale."

The numbers, while provided by only one group, support the appraisal of the conflict offered by many Syria watchers: The civil war is largely a military stalemate that is destroying the country's social fabric and taking a huge toll on civilians.

The increase also reflects the continuing spread of major hostilities to new parts of Syria. While clashes continue in Aleppo, Damascus and Homs, Syria's three largest cities, rebels have launched an offensive in recent weeks to seize towns and army bases in the southern province of Daraa, largely with the help of an influx of foreign-funded weapons.

The Observatory, which works through a network of contacts in Syria, said those killed in March included similar numbers of combatants on both sides: 1,486 rebels and army defectors and 1,464 soldiers from the Syrian army.

But the number of civilians killed exceeded them both: 2,080 total for the month, including 298 children and 291 women.

In addition, there were 387 unidentified civilians and 588 unidentified fighters, most of them foreigners fighting with the rebels, bringing the March total to 6,005, Abdul-Rahman said.

He criticized the international community for not doing more to stop the bloodshed, which he said could increase.

"If there is no solution, we think the numbers will get worse in the coming months," he said.

The March toll surpassed what had previously been the deadliest month, August 2012, when airstrikes, clashes and shelling killed more than 5,400 people, Abdul-Rahman said.

His total death toll for the conflict through the end of March was 62,554, a number he acknowledged as incomplete, suggesting the true figure could be twice as high.

Besides the underreporting of dead fighters by both sides, he mentioned the tens of thousands of missing persons and captives held by the regime and the rebels. The fate of these people is rarely uncovered, he said.

He also said more than 12,000 pro-government gunmen known as "shabiha," along with government informers may have been killed by the opposition and never reported.

The constant stream of new reports, in addition to the lack of free access to much of the country, makes full investigations impossible.

"Since there are more dying every day, it is very hard to go back and document those who died before," Abdul-Rahman said, calling for an independent international investigation inside Syria.

The Observatory's numbers are not as high as those given by the United Nations.

On Feb. 18, a U.N.-appointed Commission of Inquiry on Syria issued a 131-page report saying about 70,000 people had been killed in the conflict. The report compiled and corroborated death reports from a number of different sources.

The U.N. has not updated its number since.

The Syrian government does not provide regular death tolls for the conflict. Syrian officials did not immediately comment on the reported death toll.

Assad's regime describes the conflict as a foreign conspiracy to weaken the country carried out by terrorists on the ground.

In an attempt to boost that argument and rally regime supporters, Assad's wife, Asma, broke her long silence on the events shaking the country in a video shown on Syrian TV stations over the weekend and posted on the Internet.

In the professionally produced 14-minute video, she was seen greeting, hugging and kissing women who were described as the mothers of Syrian soldiers killed in battle.

The video, titled "With Your Soul, Protect the Jasmine," said it was filmed during a reception on Mother's Day, which is celebrated in much of the Arab world on March 21. Asma Assad, dressed casually and speaking in Arabic, thanked the mothers for their sacrifice.

"Instead of fearing for yourselves, fearing for your lives, you feared for all of Syria," she said. "Instead of your children fearing only for you, they feared for all the mothers in the country. They went to protect the country knowing that Syria, the homeland, is the mother of all."

When she finished her speech, a girls' choir broke into a patriotic song.

The video, which was posted Friday on the official Facebook page of the president's office, is the first time Asma has spoken out in public since the start of the conflict. Her silence had prompted some to speculate that the British-born first lady disapproved of the regime's violent crackdown on the opposition.

She appeared briefly at a pro-regime rally in January 2012, smiling with her children as her husband said the "conspiracy" against Syria was in its final stage.

A month later, she accompanied her husband to a polling station during a referendum on a new constitution, but did not speak.

In recent weeks, the president's office has published photos of her visiting the children of people killed in the civil war.

___

Associated Press writer Zeina Karam contributed reporting from Beirut.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-04-01-Syria/id-d0cc9b5852c14a34be1c04bb77256abc

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Monday, April 1, 2013

Astros strong in AL debut, top Texas in MLB opener

HOUSTON (AP) ? Rick Ankiel and the Houston Astros made an impressive debut in the American League, trouncing the Texas Rangers 8-2 Sunday night in the major league opener and giving Bo Porter a win in his first game as manager.

Ankiel launched a pinch-hit three-run shot for the first homer this season, Bud Norris pitched well for the win and Erik Bedard threw 3 1-3 scoreless innings for his first career save.

Having switched from the National League to the AL in the offseason, the Astros earned their first opening day victory since 2006 and the 4,000th regular-season win in franchise history.

The Astros are coming off consecutive 100-loss seasons and has the lowest payroll in the majors, prompting many to predict they will be the worst team in the majors. But Houston opened in style wearing spiffy new uniforms that brought back the orange and blue of old-school Astros teams.

Justin Maxwell added a pair of triples and made a nifty catch in center field.

Norris (1-0) allowed five hits and two runs with five strikeouts in 5 2-3 innings. He was one of five Astros making their first opening day start on baseball's second-youngest team.

Bedard shut down the Rangers on one hit the rest of the way for his first save in a 10-season career.

As Houston began a new era with the move to the AL, the Rangers were embarking on a new chapter without 2010 AL MVP Josh Hamilton. Along with Hamilton's departure to the Angels, Texas also lost catcher Mike Napoli and infielder Michael Young.

The loss snapped a streak of four straight opening day victories by the Rangers. Former Astros star Lance Berkman had two hits in his first game as Texas' designated hitter.

Matt Harrison (0-1), who signed a $55 million contract this offseason, yielded six hits and five runs and tied a career high with nine strikeouts in 5 2-3 innings.

Maxwell's two-out triple in the fourth inning broke a scoreless tie and gave Houston a 2-0 lead. The ball bounced off the wall in left field and scored Brett Wallace and Carlos Pena, who both got on with singles. Umpires reviewed the play to make sure it wasn't a home run, and upheld the call.

An error by right fielder Nelson Cruz let Houston score a run in the fifth, and Jose Altuve singled home another.

Harrison put runners at first and second with walks in the sixth and was replaced by Derek Lowe with two outs. Ankiel, the one-time pitcher with St. Louis, connected on his fifth career pinch-hit homer, a full-count shot to right field that made it 7-2.

Norris had a tough second inning and had to use 26 pitches to escape, striking out Mitch Moreland. Norris got on a roll from there, retiring nine of the next 10 batters.

Norris ran into trouble in the sixth when Ian Kinsler drew a walk and Berkman hit a one-out single. Murphy's two-out single sent Kinsler home to make it 4-1. Cruz followed with a groundball single that rolled just out of reach of diving shortstop Ronny Cedeno to score Berkman and chase Norris.

Chants of "Cruuuuuuuz" filled the stadium, indicating the large number of Rangers fans who made the 250-mile trip from Dallas. Norris was replaced by Erik Bedard, who is Houston's fifth starter, but won't be needed for a while in the rotation because of off-days.

NOTES: Altuve got the first hit of the 2013 season. ... These teams have a day off Monday before resuming the series on Tuesday when the Rangers' Yu Darvish opposes Lucas Harrell. ... Houston Texans defensive end J.J. Watt, the NFL's defensive player of the year, threw out the ceremonial first pitch. Watt, who said he threw a bullpen session to prepare for the task, threw a strike. ... Texans star receiver Andre Johnson was also in the sold-out crowd of 41,307. ... Lyle Lovett performed the national anthem.

Source: http://news.yahoo.com/astros-strong-al-debut-top-texas-mlb-opener-031532990--mlb.html

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