Thursday, May 23, 2013

Fed officials dampen talk of imminent bond buying cutback

By Jonathan Spicer and Paul Carrel

NEW YORK/FRANKFURT (Reuters) - Two senior Federal Reserve officials on Tuesday played down the chances that the U.S. central bank would signal a readiness to reduce its bond buying at its meeting next month, dampening speculation the Fed's ultra-easy monetary policy might end soon.

New York Federal Reserve Bank President William Dudley and St. Louis Fed chief James Bullard, both of whom will vote at the June 18-19 meeting, made clear further economic progress was needed before they would support curtailing bond purchases.

Wall Street stocks rallied, with both the Dow Jones industrial average and Standard & Poor's 500 Index closing at new all-time highs after their remarks eased investor concerns that the Fed would reduce its stimulus of the economy.

"Inflation is pretty low in the U.S.," Bullard told reporters after delivering a lecture in Frankfurt. "I can't envision a good case to be made for tapering unless the inflation situation turns around and we are more confident than we are today that inflation is going to move back toward target," he said.

A core inflation gauge closely monitored by the Fed slowed to just 1.1 percent per annum in March, barely half the central bank's long-term 2.0 percent annual inflation goal. In addition, the U.S. jobless rate stood at a lofty 7.5 percent in April.

The U.S. central bank has a dual mandate for price stability and maximum sustainable employment.

MARKET MOVER

In addition to boosting stocks, the U.S. dollar softened and prices for U.S. government debt moved higher on Bullard's remarks, and were given a further lift by Dudley, a close ally of Fed Chairman Ben Bernanke who said the central bank's asset purchases could go up as well as down.

Furthermore, underscoring the significant communication challenge the Fed faces if they alter the bond buying program, Dudley cautioned that investors could over-react to the first adjustment in the pace of asset purchases.

Since cutting policy interest rates to almost zero in late 2008, the Fed has more than tripled the size of its balance sheet via a campaign of massive bond purchases to hold down long-term borrowing costs and spur corporate hiring.

It decided on May 1 to keep buying at an $85 billion monthly pace, and many economists say mixed economic data warrants keeping up the purchases through year-end.

But persistent warnings from more hawkish Fed officials had fanned talk that it might start to wind back soon.

Bullard, who has been a reliable centrist in his policy votes, made clear that he did not share this view.

"I do think we should be willing and ready to change the pace of purchases when the time comes but I don't think we are there yet," he said.

Bernanke could provide more clues on the Fed's next step in testimony to the U.S. congressional Joint Economic Committee on Wednesday at 10 a.m. His remarks will be followed by the release at 2.00 p.m. of minutes of the last Fed meeting, which economists expect to give further details of how it will eventually manage the exit from ultra-easy policy.

BERNANKE ALLY

Dudley told the Japan Society in New York on Tuesday that he could not be sure whether policymakers would next reduce or increase the amount of purchases due to the "uncertain" economic outlook.

After its last meeting, the Fed said it was prepared to shift its bond buying in either direction as economic conditions warranted, and Dudley's remarks signaled that the Fed was aiming to preserve its flexibility.

Echoing past comments by both himself and Bernanke, he said the Fed might adjust the pace of bond purchases as the outlooks for inflation and the labor market change "in a material way."

While tighter fiscal policy has crimped the production, job growth, the retail sector and housing have remained surprisingly resilient.

"At some point, I expect to see sufficient evidence to make me more confident about the prospect for substantial improvement in the labor market outlook," Dudley said. "At that time, in my view, it will be appropriate to reduce the pace at which we are adding accommodation through asset purchases."

The Fed has said it will continue to buy bonds until the outlook for the job market has "improved substantially."

Dudley said the Fed would monitor the impact of fiscal drag as it weighed on policy. Economists say it likely will not be possible until at least until the third quarter to determine how big a blow belt-tightening in Washington has dealt the economy.

In a possible peak at Fed thinking on how it will eventually trim back the size of its balance sheet, Dudley also said the Fed could adjust its two-year old plan for reducing the balance sheet in the years ahead, calling parts of it "stale."

"To the extent that the committee wants to reduce the risk of disrupting market functioning during normalization, it could decide to indicate that it will avoid selling the MBS (mortgage-backed securities) portfolio during the early stages of the normalization process," he said.

"Moreover, to the extent that the committee wants to mitigate the risk of a sharp increase in long-term rates, it could judge that it would prefer not to commit to agency MBS sales."

(Additional reporting by Eva Kuehnen, writing by Alister Bull; Editing by Chizu Nomiyama)

Source: http://news.yahoo.com/fed-officials-dampen-speculation-imminent-bond-tapering-194651468.html

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Wednesday, May 22, 2013

Christie Prody, O.J. Simpson Ex-Girlfriend, Says He Threatened Her a Lot, Kind of Admitted Murders

Source: http://www.thehollywoodgossip.com/2013/05/christie-prody-oj-simpson-ex-girlfriend-says-he-threatened-her-a/

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AP PHOTOS: Devastation, reunion in tornado wake


Essential News from The Associated Press

AAA??May. 21, 2013?10:31 PM ET
AP PHOTOS: Devastation, reunion in tornado wake
By The Associated Press?THE ASSOCIATED PRESS STATEMENT OF NEWS VALUES AND PRINCIPLES?By The Associated Press

A woman walks past a pile of dead horses that were killed in a tornado a day earlier Tuesday, May 21, 2013, in Moore, Okla. A huge tornado roared through the Oklahoma City suburb Monday, flattening entire neighborhoods and destroying an elementary school with a direct blow as children and teachers huddled against winds. (AP Photo/Charlie Riedel)

A woman walks past a pile of dead horses that were killed in a tornado a day earlier Tuesday, May 21, 2013, in Moore, Okla. A huge tornado roared through the Oklahoma City suburb Monday, flattening entire neighborhoods and destroying an elementary school with a direct blow as children and teachers huddled against winds. (AP Photo/Charlie Riedel)

This Tuesday, May 21, 2013 aerial photo shows homes damaged by Monday's tornado in Moore, Oklahoma. The huge tornado roared through the Oklahoma City suburb, flattening entire neighborhoods and destroying an elementary school with a direct blow as children and teachers huddled against winds. (AP Photo/Tony Gutierrez)

An aerial view shows Briarwood Elementary with vehicles thrown about after Monday's tornado, Tuesday, May 21, 2013, in Moore, Okla. At least 24 people, including nine children, were killed in the massive tornado that flattened homes and a school in Moore, on Monday afternoon. (AP Photo/Tony Gutierrez)

Storm clouds build in the distance beyond tornado-ravaged homes Tuesday, May 21, 2013, in Moore, Okla. A huge tornado roared through the Oklahoma City suburb Monday, flattening entire neighborhoods and destroying an elementary school with a direct blow as children and teachers huddled against winds. (AP Photo/Charlie Riedel)

Kandi Scott salvages items from the rubble of her home, which she shared with her mother, until it was destroyed Monday when a tornado moved through Moore, Okla., Tuesday, May 21, 2013. The huge tornado roared through the Oklahoma City suburb, flattening entire neighborhoods and destroying an elementary school with a direct blow as children and teachers huddled against winds.(AP Photo/Brennan Linsley)

Residents sift through the remnants of their homes and parents hug children outside a demolished elementary school. Emergency workers tend to the wounded.

Here are images of the aftermath of a powerful tornado that swept through an Oklahoma City suburb, flattening neighborhoods and killing at least 24 people.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-05-21-Oklahoma%20Tornado-Photo%20Gallery/id-8ebdc7ad2cfb4a17a7d76794b7c84a1b

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FBI: Man fatally shot in Boston bombing probe

Investigators stand outside an apartment complex where a man was fatally shot when a team of FBI agents swarmed his home early Wednesday, May 22, 2013, in Orlando, Fla. The FBI says the man, being questioned by authorities in the Boston bombing probe, was fatally shot when he initiated a violent confrontation. (AP Photo/John Raoux)

Investigators stand outside an apartment complex where a man was fatally shot when a team of FBI agents swarmed his home early Wednesday, May 22, 2013, in Orlando, Fla. The FBI says the man, being questioned by authorities in the Boston bombing probe, was fatally shot when he initiated a violent confrontation. (AP Photo/John Raoux)

Police officers block the entrance to an apartment complex where man was fatally shot, Wednesday, May 22, 2013, in Orlando, Fla. The FBI says the man, being questioned by authorities in the Boston bombing probe, was fatally shot when he initiated a violent confrontation. (AP Photo/John Raoux)

(AP) ? A man being questioned by authorities in the Boston bombing probe was fatally shot when he initiated a violent confrontation, FBI officials said Wednesday.

The shooting early Wednesday took place in Orlando, Fla., where an FBI agent along with other law enforcement personnel were interviewing the man, identified as 27-year-old Ibragim Todashev.

In a statement, FBI spokesman Paul Bresson said the FBI agent acted on an imminent threat and shot Todashev.

The FBI agent was transported to a hospital with non-life threatening injuries.

An FBI team was dispatched from Washington to review the shooting, a standard step that is taken in such incidents.

Even before his encounter with the FBI, Todashev, a mixed martial arts fighter, had a recent run-in with law enforcement.

He was arrested earlier this month on a charge of aggravated battery after getting into a fight over a parking spot with a 54-year-old man and his 35-year-old son over a parking spot at an Orlando shopping mall. The 35-year-old man was hospitalized with a split upper lip and several teeth knocked out, according to a report from the Orange County Sheriff's Office.

"Also by his own admission Todashev was recently a former mixed martial arts fighter," the arresting deputy said in his report. "This skill puts his fighting ability way above that of a normal person."

Todashev was released on $3,500 bond after his May 4 arrest. His attorney, Alain Rivas, didn't immediately respond to a phone inquiry Wednesday.

Police tape blocked off the complex of townhomes near Universal Studios where Todashev was shot.

Jared Morse, who lives in the next building from Todashev's unit, said he had been watching an NBA game when he heard loud bangs that sounded like gunfire.

"It's crazy, especially in this neighborhood," Morse said as he walked his dog. "Nothing like this ever happens here."

___

Associated Press writers Pete Yost in Washington and Mike Schneider in Orlando contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-22-Boston%20Marathon%20Shooting/id-9b69081167a14000a66c38fc9b1551aa

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IRS official Lois Lerner to take the Fifth (Washington Post)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/307397080?client_source=feed&format=rss

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Saturday, May 11, 2013

Make The Most Of Your Internet Marketing With These Ideas ? Hot ...

If you?re interested in internet marketing then you may be a bit confused as to where to start, but you have to keep in mind that you can start whenever you want. The thing is, you want to make sure you?re taking the right steps and to do that, you?re going to want to learn as much as you can about internet marketing. This article is a good place to start.

One of the best things that you can do when marketing your products online is to provide free samples of your products. If advertisements do not make them buy your product, maybe free samples would. For example, if you are selling an e-book, you can give them a preview of it if they are interested in buying.

When you are trying to use internet marketing for your small business, you should take a look at the content of your site. You want make sure that the information will grab the attention of prospective customers. So, try to add new content often, to prevent people from becoming bored of your site.

Design localized content that relates to your readers on a regional level. Marketing online means you are no longer confined to advertising in a specific neighborhood, but people still appreciate information that they feel is tailored to them. Research details about an area?s needs and then show how your product will help that community.

Consider employing a specialist to do all of your internet marketing for you. Internet marketing requires a specific skill set and many people simply do not enjoy doing it. An internet marketing specialist can set up efficient internet marketing campaigns for your business and most specialists charge a very reasonable fee.

Ensure that your customers will return for future purchases by only offering quality products. Talk to people who own the products already, or buy them to try on your own. A sincere recommendation will go a long way and it will keep the customers returning to make purchases in the future.

It is natural to see your website as wonderful. After all, you created it, and it carries your hopes. But precisely because of this, you should seek out independent critical comments about your website from business professionals, friends and family, or customers. They will give you the objective vision which you do not get when looking in the mirror.

Internet marketing is becoming more and more common through social medai websites . There is an upside to this that you have a large market penetration value but there is also a downside. The downside is that many of the people who use these types of sites are very savvy about marketing.

Stay at one domain as long as possible to increase the credibility of your company on searches. The longer you stay at one domain, the higher up you will be on searches. This will allow you to increase your exposure, which goes hand in hand with the increase of sales.

Are your bookshelves groaning for relief? You can sell the books you no longer need on the internet. Choose two marketplaces: sell your cheaper books on the one with a lower commission, your more expensive books on the marketplace with a higher commission?but which has more customers and quicker turnover.

With all the information you learned in this article, you should now start feeling like you have a better idea of what strategies you want to implement towards your internet marketing goals. Remember the only way you?re going to see any kind of success, is if you actually apply the information you learned. try your best and you should be happy with the results.

This Bidify Review explains why this is a great internet business that allows you to work from home.

Source: http://hotarticledepot.com/make-the-most-of-your-internet-marketing-with-these-ideas-2/

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Saturday, May 4, 2013

This Is Earth As Seen By Smartphone Satellites

A few months ago, NASA sent some Nexus Ones into space to see if a smartphone could hold its own against the million dollar satellites already up there. The answer is "not exactly." When it comes to photography, it's probably best to stick with the space-professionals.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/Lm75k6odfAE/this-is-earth-as-seen-by-smartphone-satellites-490511420

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2016: Rare same-state pairings in the early stages

FILE - In this March 18, 2013 file photo, House Budget Committee Chairman Rep. Paul Ryan, R-Wis. is seen on Capitol Hill in Washington Wisconsin Gov. Scott Walker and his friend, Ryan, are already considered potential 2016 presidential candidates. The Republicans are part of an unusual group of potential candidates hailing from the same states, including Democrats Hillary Rodham Clinton and New York Gov. Andrew Cuomo, former Florida Gov. Jeb Bush and Sen. Marco Rubio, R-Fla., and perhaps Texas Gov. Rick Perry and freshman Sen. Ted Cruz, R-Texas. (AP Photo/J. Scott Applewhite, File)

FILE - In this March 18, 2013 file photo, House Budget Committee Chairman Rep. Paul Ryan, R-Wis. is seen on Capitol Hill in Washington Wisconsin Gov. Scott Walker and his friend, Ryan, are already considered potential 2016 presidential candidates. The Republicans are part of an unusual group of potential candidates hailing from the same states, including Democrats Hillary Rodham Clinton and New York Gov. Andrew Cuomo, former Florida Gov. Jeb Bush and Sen. Marco Rubio, R-Fla., and perhaps Texas Gov. Rick Perry and freshman Sen. Ted Cruz, R-Texas. (AP Photo/J. Scott Applewhite, File)

FILE - In this March 16, 2013 file photo, Wisconsin Gov. Scott Walker arrives to speak in National Harbor, Md. Walker and his friend, Rep. Paul Ryan, R-Wis. are already considered potential 2016 presidential candidates. The Republicans are part of an unusual group of potential candidates hailing from the same states, including Democrats Hillary Rodham Clinton and New York Gov. Andrew Cuomo, former Florida Gov. Jeb Bush and Sen. Marco Rubio, R-Fla., and perhaps Texas Gov. Rick Perry and freshman Sen. Ted Cruz, R-Texas. (AP Photo/Carolyn Kaster, File)

FILE - In this April 24, 2013 file photo, former Florida Gov. Jeb Bush speaks in Dallas. Bush and Sen. Marco Rubio, R-Fla. are among a group of potential 2016 presidential candidates hailing from the same states, including: Wisconsin Gov. Scott Walker and Rep. Paul Ryan, R-Wis., Texas Gov. Rick Perry and freshman Sen. Ted Cruz, R-Texas and New York Gov. Andrew Cuomo and Hillary Rodham Clinton. (AP Photo/Tony Gutierrez, File)

FILE - This Nov. 17, 2012, file photo shows Sen. Marco Rubio, R-Fla. speaks in Altoona, Iowa. Rubio and former Florida Gov. Jeb Bush are among a group of potential 2016 presidential candidates hailing from the same states, including: Wisconsin Gov. Scott Walker and Rep. Paul Ryan, R-Wis., former Florida Gov. Jeb Bush and Sen. Marco Rubio, R- Fla., and perhaps Texas Gov. Rick Perry and freshman Sen. Ted Cruz, R-Texas. . (AP Photo/Charlie Neibergall. File)

FILE - In this April 2, 2013 file photo, former Secretary of State Hillary Rodham Clinton speaks in Washington. Clinton and New York Gov. Andrew Cuomo are among a group of potential 2016 presidential candidates hailing from the same states, including: Wisconsin Gov. Scott Walker and Rep. Paul Ryan, R-Wis., former Florida Gov. Jeb Bush and Sen. Marco Rubio, R- Fla., and perhaps Texas Gov. Rick Perry and freshman Sen. Ted Cruz, R-Texas.(AP Photo/Cliff Owen, File)

(AP) ? The early stages of the 2016 presidential race feature an unusual cluster of high-powered potential candidates hailing from the same states, Wisconsin Gov. Scott Walker and Rep. Paul Ryan among them.

Walker gained Republican Party cult-figure status when he beat back a labor union attempt to oust him from office last year. A few weeks later, Ryan shot into the GOP stratosphere as the party's vice presidential nominee. Now, party activists view both as having serious shots at the White House should they choose to run. And their decisions ? as well as those by pairs of New Yorkers, Floridians and perhaps even Texans ? might just come down to personal conversation between longtime friends and political allies.

"At some point people are going to have to make a choice," said Brandon Scholz, a former executive director of the Wisconsin GOP. "That's a really hard choice for Republicans in Wisconsin."

Party faithful in New York, Florida and Texas face a similar predicament, with at least two possible home-state presidential candidates sharing overlapping constituencies and common financial donors. It all means that many of their friends are left watching, waiting ? and, of course, prodding ? while each weighs whether to launch a campaign.

Hillary Rodham Clinton sits atop some early polls and is the favorite among Democrats if she runs. But insiders view a fellow New Yorker, Gov. Andrew Cuomo, a former Cabinet member under her husband, President Bill Clinton, as a strong alternative if the former first lady bypasses another presidential campaign. Sen. Kirsten Gillibrand also could be a possibility in a Clinton-free New York primary.

Florida has former Gov. Jeb Bush and his political protege, Sen. Marco Rubio, both of whom are keeping their options open for 2016. Several of their closest confidants have ties to both camps, and Bush works from offices in the Biltmore Hotel in Coral Gables, just a two-mile drive from Rubio's West Miami home.

Texas has two potential Republican candidates, too: Gov. Rick Perry, whose 2012 campaign flamed out against Mitt Romney, and freshman Sen. Ted Cruz, a brash conservative who is headlining a GOP fundraiser in South Carolina on Friday that's stoking talk of a possible candidacy.

At this stage, few party loyalists expect such pairings to turn into full-fledged rivalries in the early primaries, or on debate stages. But the odd situation has forced many insiders in the potential candidates' home states to avoid playing favorites. And it has turned on its head the old notion that a state can serve as a springboard for only a single "favorite son" candidate. With online fundraising networks and the ability of wealthy donors to bankroll entire ad campaigns, multiple figures from a single state can emerge.

Rewind to 2012, when former Texas Rep. Ron Paul, a favorite among libertarians, and his home state governor, Perry, each had turns in the spotlight. Paul eventually outlasted Perry, who was staggered by poor debate performances and dropped out while the congressman stayed in the race, perhaps partly to lay the groundwork for a future presidential run by his son, Kentucky Sen. Rand Paul.

Also, in the last presidential race, former Minnesota Gov. Tim Pawlenty got an early look from Republican loyalists, and Rep. Michele Bachmann, R-Minn., later rocketed to the ranks of contenders after winning a key Iowa test vote ? a moment that forced the ex-governor to fold his campaign. In Minnesota, there were same-state troubles from the start ? Bachmann's presence froze what had been expected to be a reliable home-state fundraising base for Pawlenty. Old factions in the state's Republican ranks resurfaced, fueling a rivalry that saw Pawlenty and Bachmann clash at debates.

Any friction in the 2016 campaign remains muted for now.

In Florida, there has not been much "pressure or arm-twisting at this point," said Brett Doster, a Tallahassee-based Republican strategist who has worked with both Bush and Rubio. But he said many are watching Bush, who as the brother and son of presidents has become a senior statesman in the party.

"Until he makes that decision I think you'll see a lot of people in Florida stay on the sidelines," Doster said.

In New York this week, Cuomo countered reports that he would automatically step aside if Clinton runs.

"Hillary Clinton is going to do whatever Hillary Clinton is going to do, and I'm doing what I'm doing," Cuomo told WCNY public radio in New York.

And it's been downright Midwest collegial in Wisconsin, where Walker and Ryan will share a stage this weekend at the state Republican Party convention in Wausau.

Just two years apart in age ? Walker is 45 and Ryan is 43 ? they grew up about 20 miles from each other. Both came of age in the 1980s during Ronald Reagan's presidency and flipped hamburgers at McDonald's in high school. Both have established national followings among conservatives: Walker for his push to curtail collective bargaining rights for public sector workers and Ryan as an intellectual leader in Congress.

"In a lot of ways they're blood brothers," said Phil Musser, a former executive director of the Republican Governors Association.

Walker said in an interview that the duo often exchange text messages two or three times a day and communicate by phone or email, trading everything from Bible verses to political advice. But he said they haven't talked about the possibility of running against each other in 2016.

Ryan also tamped down the 2016 talk in an interview, calling it "an eon away in politics. It's too far away to speculate about that."

Yet, both are seeking to make their mark on the national GOP in their own ways.

Walker is speaking at conservative events around the country. Starting this month, he'll attend fundraisers for Republicans in New York and Connecticut, headline a GOP event in Iowa and raise money in Beverly Hills, Calif., for the Republican Jewish Coalition.

Ryan is focusing on Capitol Hill legislating after being the vice presidential nominee, resuming efforts to balance the federal budget in a decade and reform Medicare, all while preaching prudence and pragmatism in speeches to conservative groups.

Republican National Committee Chairman Reince Priebus, a former Wisconsin GOP chairman, said he does not expect both Ryan and Walker to run for president, and he predicted "it will all work out for the best."

"I don't know what the outcome is going to be, but the one thing I know for sure is the Wisconsin fraternity is pretty tight and it's real," Priebus said.

___

Thomas reported from Washington. Brian Bakst in St. Paul, Minn., contributed to this report.

___

Follow Scott Bauer at http://twitter.com/sbauerAP and Ken Thomas on Twitter: http://twitter.com/AP_Ken_Thomas

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-05-02-Same-State%20Politicians-2016/id-c2f8c10b45914c669c241d90eb363cb4

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Friday, May 3, 2013

CSN: Boston's five HRs help Buchholz reach 6-0

TORONTO -- For the month of April, Mike Napoli was the hottest hitter for the Red Sox and Clay Buchholz was their best starting pitcher.

Now that it's May, nothing has changed.

Buchholz dominated with seven shutout innings during which he allowed just two hits while Napoli slammed two tape-measure homers and accounted for half the Red Sox' runs in a 10-1 blowout of the Toronto Blue Jays.

The Sox belted five homers -- two from Napoli and one each from Stephen Drew, Daniel Nava and Mike Carp -- to give them 16 homers in five games against the Blue Jays this season. The club has 15 homers in its other 22 games combined.

In five games at Rogers Centre this season, the Sox have scored 36 runs -- and were shut out in one of those games.

Napoli had four RBI on the night, giving him 31 for the season.

Buchholz improved to 6-0 and lowered his ERA to 1.01 for the season. That's the lowest ERA for a Red Sox starter through the first six starts in a season since Roger Clemens had a 0.73 in 1991.

The Jays didn't advance a baserunner past first until Buchholz's final inning when Melky Cabrera singled Adam Lind (walk) to third base. They managed a run off Alex Wilson in the eighth to spoil the shutout bid.

AT A GLANCE

STAR OF THE GAME: Clay Buchholz
Buchholz tossed seven shutout innings and allowed just hits. It wasn't until his final inning of work that the Blue Jays got a baserunner into scoring position as Buchholz improved to 6-0 and lowered his ERA to 1.01.

HONORABLE MENTION: Mike Napoli
Napoli unleashed the power, with two tape-measure homers and a run-scoring double, accounting for 10 total bases and four RBI.

GOAT OF THE GAME: Mark Buehrle
The Toronto starter gave up five hits -- and three of them were homers -- as the Red Sox raced out to a 4-0 lead after four and 8-0 through the seventh, Buehrle's final inning of work.

TURNING POINT: The way Buchholz was cruising, the back-to-back homers by Napoli and Daniel Nava in the top of the fourth made it 4-0 and effectively pushed the game out of reach.

BY THE NUMBERS: With four homers in the first 27 games, Daniel Nava is one homer shy of matching his total for all of last season.

QUOTE OF NOTE: ''Obviously, pretty good.'' -- Mike Napoli, when asked how he bounced back from a four-strikeout night Tuesday night.

Source: http://www.csnne.com/blog/red-sox-talk/buchholz-napoli-lead-red-sox-blowout-blue-jays-10-1

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Allergan delays drug that would rival Regeneron's Eylea

By Esha Dey and Ransdell Pierson

(Reuters) - Allergan Inc said approval of its Darpin eye drug could be delayed up to two years, providing a new boost to Regeneron Pharmaceuticals Inc whose successful treatment, Eylea, stands to gain from a lack of new competition.

Shares of Allergan, which makes wrinkle treatment Botox, fell 13.1 percent after the company said mid-stage trial results of Darpin did not warrant an immediate move into far larger late-stage trials. Regeneron shares closed up 10.3 percent.

If eventually approved, Darpin would also compete with Roche Holding AG's, Lucentis, to treat age-related macular degeneration - the most common form of blindness in the elderly.

Adnan Butt, an analyst with RBC Capital Markets, said Darpin's delay was "great news" for Regeneron. He noted that Wall Street had feared the Allergan drug might have a superior clinical profile to Eylea.

"This gives Eylea even more time to become entrenched as the drug to beat," Butt said.

He estimates that each year of Darpin delay will translate into an upside of about $15 to $20 for Regeneron shares, now trading at about $240.

Eylea, which was approved in November 2011, had sales last year of $838 million. Regeneron expects 2013 Eylea sales of $1.2 billion to $1.3 billion. Company officials would not comment on the setback for Allergan's drug.

Regeneron is expected to report first quarter results on Friday and could update its sales projections.

Allergan Chief Executive David Pyott said on a conference call that a mid-stage trial of Darpin showed some product differentiation over Lucentis, but did not support directly moving to late-stage development.

The company now plans to perform additional mid-stage trials to assess Darpin, which will delay its potential approval by one to two years.

"There was a rush to ascribe a lot of value to Darpin and our view is that this is still very much an unproven asset with limited data," Piper Jaffray analyst David Amsellem said.

"The earliest it could get to market now is likely 2019," Amsellem said. "If you couple that with the setback of the hair loss product, the late-stage pipeline for Allergan right now is really quite thin."

A mid-stage trial of Allergan's hair loss treatment Bimatoprost Scalp also failed to provide sufficient efficacy to proceed to a late-stage study, further weighing on company shares.

ROOM TO GROW

Regeneron in the past two years has vaulted seemingly out of nowhere to become one of the world's biggest biotechnology companies, thanks largely to Eylea.

The company has repeatedly raised its sales forecasts for the drug, which is injected into the eye, as it steadily steals market share from Lucentis.

Some specialty pharmacies also use Roche's Avastin cancer drug, which works the same way as Lucentis, but is far less expensive, when divided into smaller portions for treating macular degeneration.

Roche has said that dividing Avastin through a procedure not closely monitored by health regulators, called compounding, could compromise its sterility.

Regeneron Chief Executive Leonard Schleifer said in a recent interview that sales of Eylea could jump sharply if potential rivals stumble, or if U.S. regulators clamp down on the compounding of Avastin for eye use.

Moreover, he said some analysts believe Eylea sales could swell if it is approved for a new indication called diabetic macular edema now in late-stage trials. Lucentis is already approved for the condition.

"So Eylea is a growth story unto itself, with lots of room to still grow," Schleifer said.

Allergan on Wednesday also posted a higher-than-expected quarterly profit, helped by strong sales of Botox.

Net income for the first quarter fell to $12.5 million, or 4 cents per share, due to a loss of $259 million from discontinued operations. Profit was $229.8 million, or 74 cents per share, a year earlier.

Excluding special items, Allergan earned 98 cents per share. Analysts were expecting 96 cents, according to Thomson Reuters I/B/E/S.

Global company sales rose 8 percent to $1.46 billion, above Wall Street's average estimate of $1.44 billion.

Sales of Botox, which is also approved for treating migraine headaches, overactive bladder and underarm sweating, rose 15 percent to $457.9 million.

Allergan said it now expects 2013 adjusted earnings of $4.70 to $4.76 per share, compared with its prior outlook of $4.75 to $4.83 a share.

The company forecast a second-quarter profit of $1.18 to $1.20 per share, below analysts' average estimate of $1.22 a share. The new forecasts reflect the impact of its MAP Pharmaceuticals acquisition earlier this year.

Allergan shares fell $14.88 to $98.67 on the New York Stock Exchange, while Regeneron shares rose $25.15 to $237.29.

(Reporting by Esha Dey in Bangalore and Bill Berkrot in New York; Editing by Michele Gershberg, Sreejiraj Eluvangal, Carol Bishopric and Andre Grenon)

Source: http://news.yahoo.com/allergan-delays-drug-rival-regenerons-eylea-185323020.html

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2 pounds of loose skin removed from fat Oregon dog

May 1 (Reuters) - Post position for Saturday's 139th Kentucky Derby at Churchill Downs after Wednesday's draw (listed as barrier, HORSE, jockey, trainer) 1. BLACK ONYX, Joe Bravo, Kelly Breen 2. OXBOW, Gary Stevens, D. Wayne Lukas 3. REVOLUTIONARY, Calvin Borel, Todd Pletcher 4. GOLDEN SOUL, Robby Albarado, Dallas Stewart 5. NORMANDY INVASION, Javier Castellano, Chad Brown 6. MYLUTE, Rosie Napravnik, Tom Amoss 7. GIANT FINISH, Jose Espinoza, Tony Dutrow 8. GOLDENCENTS, Kevin Krigger, Doug O'Neill 9. OVERANALYZE, Rafael Bejarano, Todd Pletcher 10. PALACE MALICE, Mike Smith, Todd Pletcher 11. ...

Source: http://news.yahoo.com/2-pounds-loose-skin-removed-fat-oregon-dog-141032272.html

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